HMGB2 also known as HMG2 is a member of the non-histone chromosomal high mobility group protein family. HMGB2 play a crucial role in regulating gene expression by influencing chromatin structure. HMGB2 binds to DNA and induces significant conformational changes, such as bending and unwinding of the DNA helix, which are essential for transcription factor accessibility to target genes. This dynamic interaction enables proper functioning of various cellular processes, including transcriptional activation, where HMGB2 collaborates with other transcription factors like Oct-2 and members of the NFκB family. Post-translational modifications, such as phosphorylation, enhance HMGB2 transcriptional activity, highlighting their importance in cellular signaling pathways.