AKR1C3 also known  as DD3 is a member of the aldo/keto reductase superfamily and plays a crucial role in steroid and xenobiotic metabolism. DD3 recognizes an enzyme that catalyzes the reduction of 3-keto-5-dihydrosteroids, essential for regulating steroid hormone levels in the body. DD3 maintains hormonal balance and influences various physiological processes, including reproduction and metabolism. Among its isoforms, DD3 uniquely catalyzes the dehydrogenation of trans-benzenedihydrodiol and trans-naphthalenedihydrodiol, highlighting specialized function in detoxifying environmental pollutants.