Q9BY76

ANGPTL4 also known as HFARP is a secreted protein that plays a crucial role in maintaining endothelial cell integrity and function, particularly under conditions of hypoxia. ANGPTL4 is induced in endothelial cells during hypoxic stress, highlighting ANGPTL4′s importance in vascular biology and response to oxygen deprivation. Structurally, ANGPTL4 features a hydrophobic N-terminal region characteristic of a secretory signal sequence, along with a consensus glycosylation site that may influence stability and activity. Notably, ANGPTL4 serves as a potential biomarker for renal cell carcinoma, as ANGPTL4 is uniquely expressed in these tumor cells, providing insights into tumor biology and potential therapeutic targets. Additionally, Angptl4 regulates glucose homeostasis, lipid metabolism, and insulin sensitivity, making ANGPTL4 a significant factor in metabolic disorders such as diabetes.