O60238

Nix also known as BNIP3L, Nip3L is a protein that belongs to the pro-apoptotic subfamily within the Bcl-2 family of proteins. Nix is a pro-apoptotic member of the Bcl-2 family, and its function is intricately regulated by post-translational modifications such as phosphorylation and ubiquitination. These modifications are critical for controlling Nix′s stability, subcellular localization, and interactions with other proteins involved in apoptotic signaling pathways. The structural integrity and regulation of Nix through these modifications enable Nix to effectively localize to the mitochondria, where Nix interacts with anti-apoptotic proteins like Bcl-xL to initiate programmed cell death, a vital process for maintaining cellular homeostasis.