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DSPP also known as Dentin sialophosphoprotein is a member of the small integrin-binding ligand N-linked glycoprotein (SIBLING) family of proteins. DSPP serves as a precursor that is cleaved into two functional proteins: dentin sialoprotein (DSP) and dentin phosphoprotein (DPP). These proteins are integral components of the dentin extracellular matrix in teeth, with DSP playing a crucial role in dentinogenesis, while DPP is essential for binding calcium, which facilitates the initial mineralization of the dentin matrix collagen and regulates the size and shape of mineral crystals. Proper functioning of DSPP is vital for tooth development and integrity, as mutations in the DSPP gene can lead to conditions such as DFNA39/DGI1, characterized by progressive hearing loss and dentinogenesis imperfecta, as well as DGI2 and DGI3, which result in brittle, discolored teeth.