P12830

E-cadherin aslo knonw as Cadherin 1, CDH1 is a classical cadherin of the cadherin superfamily. E-cadherin plays a crucial role in maintaining epithelial integrity and tissue architecture by facilitating cell-cell adhesion, which is essential for proper morphogenesis and the prevention of tumor metastasis. E-cadherin is primarily located at the cell membrane, where E-cadherin forms adherens junctions with neighboring cells, thereby contributing to the formation of tight epithelial layers. E-cadherin′s location at the membrane is critical, as dysfunction or loss is often associated with increased cellular motility and invasiveness, hallmark features of cancer progression. E-cadherin′s extracellular domain is characterized by a series of five homologous repeats that are vital for adhesive properties, while E-cadherin′s intracellular domain interacts with cytoplasmic proteins like β-catenin, linking to the actin cytoskeleton and influencing cellular signaling pathways.