Q13480

Gab1 is a member of the IRS1-like multisubstrate docking protein family. Gab1 plays a crucial role in cellular signaling pathways, particularly in growth factor receptor activation. Gab1 functions as an adapter protein that facilitates signal transmission from activated receptor tyrosine kinases to downstream signaling molecules, influencing cellular responses such as proliferation and differentiation. Gab1 is essential in epidermal growth factor receptor (EGFR) and insulin receptor signaling pathways, where Gab1 forms complexes with other adapter proteins like GRB2 and Sos, linking these receptors to the Ras signaling pathway. This interaction regulates various cellular processes, including metabolism and cell growth, making Gab1 crucial for maintaining cellular homeostasis and responding to external growth signals.