Polyclonal Antibodies - PXR Rabbit Polyclonal Antibody

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PXR Rabbit Polyclonal Antibody

Catalog #：EAB13938

Datasheet

SKU-Pack Size	Availability	Size	Price
EAB13938-30UL	In Stock	30ul	￡97.90
EAB13938-100UL	In Stock	100ul	￡218.90
EAB13938-200UL	In Stock	200ul	￡372.90

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	CUlabSciences	Phone：+44 (0) 1232 330008
	Cambridge House St Thomas' Place Ely,	E-mail：sales@culabsciences.co.uk
United Kingdom	Cambridge CB27 9RD UK	Web：www.culabsciences.co.uk

Product Information
Applications	WB, ELISA
Species Reactivity	Human, Mouse, Rat
Host / Isotype	Rabbit IgG
Clonality	Polyclonal
Applications Dilutions	WB=1:500-2000
MW (kDa)	49
Conjugate	Unconjugate
Specificity	PXR Rabbit Polyclonal Antibody detects endogenous levels of PXR protein.
Purification	Affinity purification
Concentration	1mg/ml
Format	Liquid
Formulation	In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol.
Shipping	Gel Pack
Storage	Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks.
Research Use	For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Application Key WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IF-Immunofluorescence ICC-Immunocytochemistry FC-Flow Cytometry
Reactivity Key H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish Hr-Horse All-All Species Expected

Product Bioinformatics
Synonym(s)	Nuclear receptor subfamily 1 group I member 2; Pregnane X Receptor; BXR; PAR; PRR; PXR; SAR; SXR; ONR1; PAR1; PAR2; PARq; NR1I2
Gene Aliases	NR1I2
UniProt ID	O75469
Entrez Gene ID	8856

Product Description

PXR(Pregnane X Receptor) also known as NR1I2 is a member of the nuclear receptor superfamily. PXR plays a crucial role in the regulation of gene expression by acting as a sensor for a wide range of endogenous and exogenous compounds, including steroids and drugs. Located primarily in the nucleus, PXR functions as a transcription factor that, upon binding to ligands, forms a heterodimer with retinoid X receptor (RXR) and subsequently binds to specific DNA sequences to modulate the expression of target genes involved in drug metabolism and transport. This localization enables PXR to directly influence cellular response to various substances, thereby playing a significant role in pharmacogenomics and the body′s ability to process medications.

Product Image Gallery
Western blot analysis of extracts on CACO2, Rat Intestine cells, using PXR Rabbit Polyclonal Antibody (EAB13938) at 1:1000 dilution. Secondary antibody Goat Anti-Rabbit IgG (H&L)-HRP (EAB21002) at 1:5000 dilution.

Specific Protocols

>>	Western Blotting Protocol	>>	Immunoprecipitation Protocol
>>	Immunohistochemistry Protocol	>>	Immunofluorescence Protocol
>>	Immunocytochemistry Protocol	>>	Flow Cytometry Protocol
>>	ChIP Protocol	>>	ELISA Protocol
>>	HPLC Protocol	>>	PCR Protocol