S100A12 also known as Calgranulin C, CGRP, EN-RAGE is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100A12 plays a crucial role in immune response, particularly in the activation and recruitment of immune cells during inflammation. S100A12 is primarily expressed in macrophages and epithelial cells, where S100A12 acts as a pro-inflammatory mediator, influencing the behavior of various immune cells and contributing to the pathophysiology of several inflammatory diseases. The ability of S100A12 to interact with specific proteins, such as receptor for advanced glycation end products (RAGE), underscores its importance in cellular signaling pathways that regulate inflammation and tissue repair.