Somatostatin(SST) is a crucial regulatory hormone that plays a significant role in inhibiting the release of several secondary hormones by binding to high-affinity G protein-coupled somatostatin receptors. This cyclic tetradecapeptide is essential for regulating the secretion of key hormones such as growth hormone, insulin, and glucagon, thereby influencing metabolic processes. Somatostatin is predominantly located in the hypothalamus and pancreas, where Somatostatin regulates insulin synthesis. Somatostatin exists in two active forms, Somatostatin-14 and Somatostatin-28, which are generated through the alternate cleavage of a single preproprotein encoded by the gene. Somatostatin has been shown to modulate neurotransmission rates in the central nervous system and influence the proliferation of both normal and tumorigenic cells, highlighting Somatostatin′s importance in various physiological and pathological processes.