O43151

TET3(Tet oncogene family member 3) is a 1660 amino acid protein that plays a crucial role in DNA demethylation, a process essential for regulating gene expression and maintaining cellular identity. TET3 function is particularly important in development and differentiation, as aberrations in DNA methylation patterns can lead to various diseases, including cancer. TET3 is expressed in several tissues, including the fetal and adult brain, muscle, colon, and adrenal gland, and exists in multiple alternatively spliced isoforms, which may contribute to diverse functional roles. Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; methyl-CpG binding activity; and zinc ion binding activity. Involved in positive regulation of transcription by RNA polymerase II and protein O-linked glycosylation.