P16473

TSHR also known as LGR3, Thyrotropin Receptor is a membrane protein and a major controller of thyroid cell metabolism. TSHR plays a crucial role in regulating thyroid function by mediating the effects of thyroid-stimulating hormone (TSH), which is essential for maintaining thyroid structure and metabolism. TSHR is located on the surface of thyroid follicular cells, where TSH binding leads to the activation of intracellular signaling pathways that stimulate the production and release of thyroid hormones. Such regulation is vital for numerous physiological processes, including metabolism, growth, and development. TSHR undergoes post-translational modifications, such as glycosylation, which are important for stability, localization, and function. These modifications can influence receptor activity and are critical for proper signaling, highlighting TSHR′s importance in endocrine health.