UHRF1 also known as Np95 is a member of a subfamily of RING-finger type E3 ubiquitin ligases. UHRF1 is predominantly localized in the nucleus, where UHRF1 plays a vital role in cellular proliferation by functioning as an E3 ubiquitin-protein ligase. UHRF1 facilitates the transfer of ubiquitin from an E2 ubiquitin-conjugating enzyme to target proteins, marking them for degradation, which is essential for maintaining cellular homeostasis and regulating the cell cycle. Additionally, UHRF1 directly interacts with Dnmt1, a maintenance DNA methyltransferase, ensuring stable association with chromatin, which is critical for proper regulation of gene expression and epigenetic inheritance. The overexpression of UHRF1 in cancer cells highlights UHRF1′s potential involvement in carcinogenesis, making UHRF1 a significant target for research in cancer biology.