GLP1R(Glucagon like peptide 1 receptor) is a 7-transmembrane protein that functions as a receptor for glucagon-like peptide 1 (GLP-1) hormone, which stimulates glucose-induced insulin secretion. GLP1R protein plays a crucial role in glucose metabolism and appetite regulation, as GLP1R is primarily located in the hypothalamus, a brain region that governs feeding behavior. This localization is significant because GLP1R mediates the effects of glucagon-like peptide-1 (GLP-1), which not only enhances insulin secretion but also suppresses appetite, making GLP1R a vital target for diabetes and obesity therapies. The interaction between GLP-1 and GLP1R is essential for maintaining glucose homeostasis, and dysregulation of this pathway can lead to metabolic disorders.