Q15648

TRAP220 also known as MED1 is integral to forming functional transcriptional machinery. TRAP220 is primarily located in the nucleus, where TRAP220 facilitates hormone-induced transcriptional activation by binding to nuclear receptors, including thyroid hormone receptors and vitamin D receptors. Nuclear localization of TRAP220 allows precise regulation of gene expression in response to hormonal signals, impacting various physiological processes such as metabolism, development, and cellular differentiation. TRAP220 is widely expressed in tissues such as skeletal muscle, heart, and placenta, highlighting TRAP220′s importance in both developmental and metabolic pathways. Through interactions with other components of the TRAP complex, making TRAP220 a significant target for studies related to gene regulation and endocrine signaling.