NSD1 is a protein containing a SET domain, 2 LXXLL motifs, 3 nuclear translocation signals (NLSs), 4 plant homeodomain (PHD) finger regions, and a proline-rich region.NSD1 plays a crucial role in gene regulation and is involved in various cellular processes, including transcriptional activation and repression, which are vital for normal cellular function and development. NSD1 is predominantly located in the nucleus, where NSD1 interacts with chromatin and transcription factors to modulate gene expression. NSD1′s nuclear localization influences the transcriptional landscape of the cell, thereby impacting processes such as cell growth and differentiation.