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Src-3 also known as RAC3, ACTR, AIB-1, p/CIP, NCoA-3, plays a crucial role as a transcriptional coactivator in the steroid receptor family, facilitating the transcriptional activation of hormone-responsive genes. NCoA-3 is particularly significant due to its involvement in the regulation of gene expression linked to various physiological processes, including cell growth and differentiation. Notably, NCoA-3 is often overexpressed in estrogen receptor-positive ovarian and breast cancers, highlighting its importance in cancer biology and potential as a therapeutic target. The interaction of NCoA-3 with other proteins, such as p300/CBP, underscores its role in enhancing transcriptional activity, making NCoA-3 a vital component in the signaling pathways that govern cellular responses to hormones.