P18887

XRCC1 is involved in the efficient repair of DNA single-strand breaks formed by exposure to ionizing radiation and alkylating agents. XRCC1 plays a crucial role in the DNA base excision repair pathway, which is essential for maintaining genomic integrity by repairing single-strand breaks in DNA. XRCC1 acts as a scaffold that facilitates the recruitment of various DNA repair proteins, including DNA ligase III and DNA polymerase, thereby ensuring efficient repair processes. The importance of XRCC1 is underscored by its involvement in preventing mutations that could lead to cancer and other genetic disorders. Additionally, defects in XRCC1 can compromise the DNA repair mechanism, leading to increased susceptibility to DNA damage and contributing to the development of various diseases.