Polyclonal Antibodies - Phospho-p70 S6 kinase β (Ser423) Rabbit Polyclonal Antibody

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Phospho-p70 S6 kinase β (Ser423) Rabbit Polyclonal Antibody

Catalog #：EAB14461

Datasheet

SKU-Pack Size	Availability	Size	Price
EAB14461-30UL	In Stock	30ul	￡119.90
EAB14461-100UL	In Stock	100ul	￡251.90
EAB14461-200UL	In Stock	200ul	￡405.90

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	CUlabSciences	Phone：+44 (0) 1232 330008
	Cambridge House St Thomas' Place Ely,	E-mail：sales@culabsciences.co.uk
United Kingdom	Cambridge CB27 9RD UK	Web：www.culabsciences.co.uk

Product Information
Applications	WB, ELISA
Species Reactivity	Human, Mouse
Host / Isotype	Rabbit IgG
Clonality	Polyclonal
Applications Dilutions	WB=1:500-2000
MW (kDa)	53
Conjugate	Unconjugate
Specificity	Phospho-p70 S6 kinase β (Ser423) Rabbit Polyclonal Antibody detects endogenous levels of p70 S6 kinase β only when phosphorylated at Ser423.
Purification	Affinity purification
Concentration	1mg/ml
Format	Liquid
Formulation	In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol.
Shipping	Gel Pack
Storage	Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks.
Research Use	For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Application Key WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IF-Immunofluorescence ICC-Immunocytochemistry FC-Flow Cytometry
Reactivity Key H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish Hr-Horse All-All Species Expected

Product Bioinformatics
Synonym(s)	Ribosomal protein S6 kinase B2; KLS; SRK; S6K2; S6KB; STK14B; S6KI(2); S6Kbeta; p70S6Kb; P70-beta; S6K-beta2; P70-beta-1; P70-beta-2; p70(S6K)-beta; RPS6KB2
Gene Aliases	RPS6KB2
UniProt ID	Q9UBS0
Entrez Gene ID	6199

Product Description

p70 S6 kinase β also known as S6Kbeta, P70S6Kb, RPS6KB2 is a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. p70 S6 kinase β plays a crucial role in regulating protein synthesis and cell growth, primarily by phosphorylating ribosomal protein S6, which is essential for translating mRNAs that encode proteins involved in cell cycle progression and metabolism. p70 S6 kinase β is activated in response to growth factors and is part of a signaling cascade that includes the ERK MAP kinase family, which is regulated by upstream kinases such as MEK. Precise regulation of p70 S6 kinase β is vital for maintaining cellular homeostasis and responding to external stimuli, making p70 S6 kinase β a significant target for research in cancer and metabolic disorders.

Product Image Gallery
Western blot analysis of extracts on K562 cells treated with EGF, using Phospho-p70 S6 kinase β (Ser423) Rabbit Polyclonal Antibody (EAB14461) at 1:1000 dilution. The lane on the left is blocked with the phospho peptide.

Specific Protocols

>>	Western Blotting Protocol	>>	Immunoprecipitation Protocol
>>	Immunohistochemistry Protocol	>>	Immunofluorescence Protocol
>>	Immunocytochemistry Protocol	>>	Flow Cytometry Protocol
>>	ChIP Protocol	>>	ELISA Protocol
>>	HPLC Protocol	>>	PCR Protocol