Monoclonal Antibodies - CD8a Mouse Monoclonal Antibody

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CD8a Mouse Monoclonal Antibody

Catalog #：EAB21325

Datasheet

	SKU-Pack Size	Availability	Size	Price
	EAB21325-100UL	In Stock	100ul	€297.70

If you want to get a larger packsize, Please contact your local distributor or
email us at info@ebiocell.com

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	Dianost	Phone：+49 (0) 40 65472-053
	Bullenkoppel 11， 23896 Poggensee,	E-mail：ola@olasciences.com
Germany	Germany	Web：www.olasciences.com

Product Information
Applications	WB, IHC-P, IF/ICC, ELISA
Species Reactivity	Human, Mouse
Host / Isotype	Mouse IgG1
Clonality	Monoclonal
Applications Dilutions	WB=1:500-2000　 IHC-P=1:100-500　 IF/ICC=1:100-500
MW (kDa)	26
Conjugate	Unconjugate
Specificity	CD8a Mouse Monoclonal Antibody detects endogenous levels of CD8a protein.
Purification	Affinity purification
Concentration	1mg/ml
Format	Liquid
Formulation	In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol.
Shipping	Gel Pack
Storage	Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks.
Research Use	For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Application Key WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IHC-P-Immunohistochemistry-Paraffin IF-Immunofluorescence ICC-Immunocytochemistry FC-Flow Cytometry
Reactivity Key H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish Hr-Horse All-All Species Expected

Product Bioinformatics
Synonym(s)	CD8 subunit alpha; CD8; p32; Leu2; IMD116; CD8alpha; CD8A
Gene Aliases	CD8A
UniProt ID	P01732
Entrez Gene ID	925

Product Description

CD8a also known as CD8α, Leu-2, T8, CD8alpha is a transmembrane glycoprotein expressed on the surface of cytotoxic T lymphocytes and some natural killer cells. CD8a plays a crucial role in adaptive immune response. Structurally, CD8a forms either homodimers (αα) or heterodimers with CD8-β (αβ), featuring an extracellular immunoglobulin-like domain that binds to the α3 domain of major histocompatibility complex (MHC) class I molecules presented by antigen-presenting cells (APCs). This structural configuration facilitates interaction between T cells and APCs, enhancing antigen recognition and signal transduction through T cell receptor (TCR). Any alterations in CD8a′s structure can affect immune surveillance and cytotoxic T cells′ ability to identify and eliminate infected or malignant cells.

Product Image Gallery
Western blot analysis of extracts on Mouse thymus cells, using CD8a Mouse Monoclonal Antibody (EAB21325) at 1:1000 dilution. Secondary antibody Goat Anti-Mouse IgG (H&L)-HRP (EAB21001) at 1:5000 dilution. Immunohistochemical analysis of paraffin-embedded Human tonsil tissue, using CD8a Mouse Monoclonal Antibody (EAB21325) at 1:200 dilution.

Specific Protocols

>>	Western Blotting Protocol	>>	Immunoprecipitation Protocol
>>	Immunohistochemistry Protocol	>>	Immunofluorescence Protocol
>>	Immunocytochemistry Protocol	>>	Flow Cytometry Protocol
>>	ChIP Protocol	>>	ELISA Protocol
>>	HPLC Protocol	>>	PCR Protocol