ADK also known as AK is an enzyme which catalyzes the transfer of the gamma-phosphate from ATP to adenosine, thereby serving as a regulator of concentrations of both extracellular adenosine and intracellular adenine nucleotides. ADK plays a crucial role in cellular metabolism by catalyzing the transfer of the gamma-phosphate from ATP to adenosine, thereby regulating the levels of extracellular adenosine and intracellular adenine nucleotides. This regulation is particularly important as adenosine acts as a signaling molecule that influences various physiological processes, including cardiovascular function, neuronal activity, and immune responses. Elevated levels of adenosine are often observed in tissues undergoing injury or inflammation, where adenosine serves to modulate the inflammatory response and protect against excessive neuronal excitability, making ADK a key player in maintaining homeostasis.