NFIB also known as NF1B is a member of the NF1 (nuclear factor 1) family of transcription factors. NFIB plays a crucial role in different aspects of tumor development, acting as an oncogene or tumor suppressor in different types of tumors and participating in tumor-associated fusion gene formation. Moreover, NFIB has been shown to promote epithelial-mesenchymal transition and metastatic ability of cancer cells through a number of mechanisms, including upregulating SNAI1 expression in colorectal cancer, stabilizing chromatin accessibility in small cell lung cancer, and modulating the ZEB1 axis in melanoma.