WAVE3 also known as SCAR3, WASF3 is a member of the Wiskott-Aldrich syndrome protein family. WASF3 plays a crucial role in actin cytoskeletal dynamics, which is essential for various cellular processes, including cell motility, shape changes, and signal transduction. This interaction is vital for processes such as cell migration and morphogenesis, making WAVE3 a significant player in both normal physiological functions and pathological conditions, including cancer metastasis. The WAVE family, including WAVE1 and WAVE2, cooperates with the Arp2/3 complex to promote actin filament formation, thereby influencing cellular architecture and behavior. WAVE3 mediates actin polymerization in response to GTP binding and activation of Rac, underscoring its importance in maintaining cellular integrity and facilitating dynamic responses to environmental cues.