IFRD2(Interferon-related developmental regulator 2) also known as SKMc15 is a 442 amino acid soluble nuclear protein that plays a crucial role in cellular processes. IFRD2 is ubiquitously expressed and features a β-catenin-like repeat, suggesting involvement in the adenomatous polyposis coli (APC) signaling pathway, which is vital for regulating cell growth and differentiation. IFRD2 shares 75% homology with IFRD1 and may influence the expression of surface adhesion molecules essential for the differentiation and fusion of myogenic satellite cells, which are critical for muscle regeneration. While the gene encoding IFRD2 is subject to overlapping homozygous deletions in various lung cancer cell lines, IFRD2 does not exhibit loss-of-function mutations in cancer cells, indicating a potential role in tumor progression and highlighting importance in cancer biology.