Polyclonal Antibodies - FCGR2B/CD32b Rabbit Polyclonal Antibody

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FCGR2B/CD32b Rabbit Polyclonal Antibody

Catalog #：EAB14906

Datasheet

SKU-Pack Size	Availability	Size	Price
EAB14906-30UL	In Stock	30ul	€115.70
EAB14906-100UL	In Stock	100ul	€258.70
EAB14906-200UL	In Stock	200ul	€440.70

If you want to get a larger packsize, Please contact your local distributor or
email us at info@ebiocell.com

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	Betaclonal	Phone：+34 (0)91 471 6763
	29/1 Lomonosovsky Pr,	E-mail：tech@betaclonal.com
Spain	Madrid, Spain	Web：www.betaclonal.com

Product Information
Applications	WB, IHC-P, IF, ELISA
Species Reactivity	Human, Mouse, Rat
Host / Isotype	Rabbit IgG
Clonality	Polyclonal
Applications Dilutions	WB=1:500-2000　 IHC-P=1:50-300　 IF=1:50-300
MW (kDa)	34
Conjugate	Unconjugate
Specificity	FCGR2B/CD32b Rabbit Polyclonal Antibody detects endogenous levels of FCGR2B/CD32b protein.
Purification	Affinity purification
Concentration	1mg/ml
Format	Liquid
Formulation	In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol.
Shipping	Gel Pack
Storage	Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks.
Research Use	For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Application Key WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IHC-P-Immunohistochemistry-Paraffin IF-Immunofluorescence ICC-Immunocytochemistry FC-Flow Cytometry
Reactivity Key H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish Hr-Horse All-All Species Expected

Product Bioinformatics
Synonym(s)	Fc gamma receptor IIb; CD32; FCG2; CD32B; FCGR2; IGFR2; FCGR2C; FcGRIIB; FcRII-c; FcgammaRIIb; FCGR2B
Gene Aliases	FCGR2B
UniProt ID	P31994
Entrez Gene ID	2213

Product Description

FCGR2B also designated Fc gamma RIIb, CD32b is a low affinity receptor for the Fc region of immunoglobulin gamma complexes. FCGR2B plays a crucial role in the immune response by mediating the clearance of immune complexes through macrophages. This function is vital for maintaining homeostasis and preventing autoimmune reactions. Additionally, FCGR2B is involved in the regulation of antibody production by B cells, where FCGR2B interaction with IgG delivers a negative signal that modulates B cell activity. FCGR2B exists in several isoforms, produced by alternative splicing of three distinct genes (A, B, and C), which are designated FcgRIIA, FcgRIIB1, FcgRIIB3, and FcgRIIC. These isoforms are expressed on various immune cells, including monocytes, placental trophoblasts, and endothelial cells, with specific forms present on B lymphocytes and neutrophils, highlighting FCGR2B′s diverse roles in immune regulation and response.

Product Image Gallery
Western blot analysis of extracts on Hela, HepG2, SH-SY5Y, Rat liver cells, using FCGR2B/CD32b Rabbit Polyclonal Antibody (EAB14906) at 1:1000 dilution. Secondary antibody Goat Anti-Rabbit IgG (H&L)-HRP (EAB21002) at 1:5000 dilution. Immunohistochemistry of paraffin-embedded Human liver cancer tissue, using FCGR2B/CD32b Rabbit Polyclonal Antibody (EAB14906) at 1:200 dilution.

Specific Protocols

>>	Western Blotting Protocol	>>	Immunoprecipitation Protocol
>>	Immunohistochemistry Protocol	>>	Immunofluorescence Protocol
>>	Immunocytochemistry Protocol	>>	Flow Cytometry Protocol
>>	ChIP Protocol	>>	ELISA Protocol
>>	HPLC Protocol	>>	PCR Protocol