Other Biochemicals - Trabectedin (CAS: 114899-77-3)

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Trabectedin (CAS: 114899-77-3)

Catalog #：EBC51168

Datasheet

Trabectedin (CAS: 114899-77-3)

SKU-Pack Size	Availability	Size	Price
EBC51168-1MG	In Stock	1mg	￡218.90
EBC51168-5MG	In Stock	5mg	￡438.90

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Product Information

Synonym(s)

Trabectedin; Ecteinascidin 743; ET-743; ET743

CAS Number

114899-77-3

Purity

≥98.0%

Molecular Weight

761.84

Molecular Formula

C39H43N3O11S

SMILES

CC1=C(OC)C(O)=C2C3[C@@H]4[C@@H]5C6=C(C7=C(OCO7)C(C)=C6OC(C)=O)[C@@H](COC(C8(C9=CC(OC)=C(O)C=C9CCN8)CS5)=O)N4C(O)C(CC2=C1)N3C

Solubility

DMSO: 33.33 mg/mL (43.75 mM; Need ultrasonic)

Preparing Stock Solutions

ConcentrationSolventMass	1 mg	5 mg	10 mg
1 mM	1.3126 ml	6.5631 ml	13.1261 ml
5 mM	0.2625 ml	1.3126 ml	2.6252 ml
10 mM	0.1313 ml	0.6563 ml	1.3126 ml
50 mM	0.0263 ml	0.1313 ml	0.2625 ml

Shipping

Gel Pack

Storage

Store at -20°C

Research Use

For Research Use Only. Not Intended for Diagnostic Or Therapeutic Use.

Product Description

Trabectedin (Ecteinascidin 743) is deuterium labeled Trabectedin. Trabectedin is a tetrahydroisoquinoline alkaloid with potent antitumor activity. Trabectedin binds to the minor groove of DNA, blocks transcription of stress-induced proteins, induces DNA backbone cleavage and cancer cells apoptosis, and increases the generation of ROS in MCF-7 and MDA-MB-453 cells. Trabectedin has tje potential for soft tissue sarcoma and ovarian cancer treatment.

Specific Protocols

>>	Western Blotting Protocol	>>	Immunoprecipitation Protocol
>>	Immunohistochemistry Protocol	>>	Immunofluorescence Protocol
>>	Immunocytochemistry Protocol	>>	Flow Cytometry Protocol
>>	ChIP Protocol	>>	ELISA Protocol
>>	HPLC Protocol	>>	PCR Protocol