Monoclonal Antibodies - Tyk2 Mouse Monoclonal Antibody

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Tyk2 Mouse Monoclonal Antibody

Catalog #：EAB21417

Datasheet

	SKU-Pack Size	Availability	Size	Price
	EAB21417-100UL	In Stock	100ul	€336.70

If you want to get a larger packsize, Please contact your local distributor or
email us at info@ebiocell.com

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	OlaSciences	Phone：+33 (0) 9 77 4001 556
	87, rue des Suisses 65000 Nanterre,	E-mail：ola@olasciences.com
France	France	Web：www.olasciences.com

Product Information
Applications	WB, IHC-P, IF/ICC, ELISA
Species Reactivity	Human, Mouse, Rat
Host / Isotype	Mouse IgG2b
Clonality	Monoclonal
Applications Dilutions	WB=1:1000-5000　 IHC-P=1:100-500　 IF/ICC=1:100-500
MW (kDa)	134
Conjugate	Unconjugate
Specificity	Tyk2 Mouse Monoclonal Antibody detects endogenous levels of Tyk2 protein.
Purification	Affinity purification
Concentration	1mg/ml
Format	Liquid
Formulation	In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol.
Shipping	Gel Pack
Storage	Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks.
Research Use	For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Application Key WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IHC-P-Immunohistochemistry-Paraffin IF-Immunofluorescence ICC-Immunocytochemistry FC-Flow Cytometry
Reactivity Key H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish Hr-Horse All-All Species Expected

Product Bioinformatics
Synonym(s)	Tyrosine kinase 2; JTK1; IMD35; TYK2
Gene Aliases	TYK2
UniProt ID	P29597
Entrez Gene ID	7297

Product Description

Tyk2 is a crucial member of the non-receptor Janus tyrosine kinase family, playing a pivotal role in mediating cellular responses to cytokines and interferons, which are essential for the immune system′s functionality. Located primarily in the cytoplasm, Tyk2 is recruited to activated cytokine receptors, where Tyk2 phosphorylates signal transducer and activator of transcription (STAT) proteins. This phosphorylation triggers the dimerization of STATs, allowing STATs to translocate to the nucleus and regulate the transcription of genes involved in immune responses. Proper functioning of Tyk2 is critical for maintaining immune homeostasis, as dysregulation can lead to various inflammatory diseases.

Product Image Gallery
Western blot analysis of extracts on K562, Jurkat, Molt-4, HEK293 cells, using Tyk2 Mouse Monoclonal Antibody (EAB21417) at 1:2000 dilution. Secondary antibody Goat Anti-Mouse IgG (H&L)-HRP (EAB21001) at 1:5000 dilution.

Specific Protocols

>>	Western Blotting Protocol	>>	Immunoprecipitation Protocol
>>	Immunohistochemistry Protocol	>>	Immunofluorescence Protocol
>>	Immunocytochemistry Protocol	>>	Flow Cytometry Protocol
>>	ChIP Protocol	>>	ELISA Protocol
>>	HPLC Protocol	>>	PCR Protocol