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Glucocorticoid Receptor/GR Rabbit Monoclonal Antibody
Catalog #:EAB22658
  SKU-Pack Size Availability Size Price
EAB22658-100UL In Stock 100ul ¥2290.00
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Product Information
Applications WB, IP, IHC-P, IF/ICC
Species Reactivity Human, Mouse, Rat
Host / Isotype Rabbit IgG
Clonality Monoclonal
Applications Dilutions WB=1:1000-5000 
IP=1:10-100
IHC-P=1:100-500 
IF/ICC=1:100-500
MW (kDa) 86
Conjugate Unconjugate
Specificity Glucocorticoid Receptor/GR Rabbit Monoclonal Antibody detects endogenous levels of Glucocorticoid Receptor/GR protein.
Purification Affinity purification
Concentration 1mg/ml
Format Liquid
Formulation In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol.
Shipping Gel Pack
Storage Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks.
Research Use For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Application Key

WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IHC-P-Immunohistochemistry-Paraffin
IF
-Immunofluorescence ICC-Immunocytochemistry FC-Flow Cytometry

Reactivity Key

H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish
Hr
-Horse All-All Species Expected

Product Bioinformatics
Synonym(s) Glucocorticoid Receptor; GCCR; GCR; GCRST; GR; GRL; Grl-1; Grl1; NR3C1
Gene Aliases NR3C1
UniProt ID

P04150

Entrez Gene ID

2908

Product Description

GR (glucocorticoid receptor) also known as NR3C1 is a critical transcription factor that plays a vital role in mediating the physiological effects of glucocorticoids, which are steroid hormones involved in numerous biological processes such as metabolism, immune response, and stress regulation. GR is predominantly located in the cytoplasm, where GR exists in an inactive form bound to heat shock proteins, particularly HSP90. Upon binding to glucocorticoids, GR translocates to the nucleus, where GR regulates gene expression by either inducing or repressing target genes. This translocation allows GR to interact with specific DNA sequences and recruit co-regulators that modulate transcription. GR′s ability to influence gene expression is essential for maintaining homeostasis and responding to environmental changes, making GR a significant target for therapeutic interventions in conditions such as inflammation, autoimmune diseases, and cancer. 

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Specific Protocols
>> Western Blotting Protocol >> Immunoprecipitation Protocol
>> Immunohistochemistry Protocol >> Immunofluorescence Protocol
>> Immunocytochemistry Protocol >> Flow Cytometry Protocol
>> ChIP Protocol >> ELISA Protocol
>> HPLC Protocol >> PCR Protocol
For Research Use Only, Not For Diagnostic Or Therapeutic Procedures.
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