P29353

Shc also known as SHCA, SHC1 is a critical adapter protein that plays a pivotal role in signaling pathways activated by receptor tyrosine kinases, which are essential for various cellular responses, including growth and differentiation. Located primarily in the cytoplasm, Shc acts as a molecular bridge, linking activated receptors to downstream signaling molecules, thereby facilitating signal transmission to the nucleus. This function allows cells to respond appropriately to external growth signals, ensuring proper cellular function and homeostasis. Notably, Shc interacts with other key proteins, such as GRB2 and Sos, to activate the Ras signaling pathway, which is vital for cell proliferation and survival.