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Shc Rabbit Monoclonal Antibody
Catalog #:EAB21252
  SKU-Pack Size Availability Size Price
EAB21252-100UL In Stock 100ul ¥2290.00
If you want to get a larger packsize, Please contact your local distributor or
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北京美瑞克生物科技有限公司 Phone:  +86 010-62890160 / 13691184142(微信同号)
2 / F, 128 malianwa North Road, Haidian District, E-mail:   mrkbio@163.com 
China Beijing China Website: www.mrkbio.com
Product Information
Applications WB, IHC-P, IF/ICC, FC
Species Reactivity Human, Mouse, Rat
Host / Isotype Rabbit IgG
Clonality Monoclonal
Applications Dilutions WB=1:500-2000 
IHC-P=1:50-200 
IF/ICC=1:50-200 
FC=1:10-100
MW (kDa) 63
Conjugate Unconjugate
Specificity Shc Rabbit Monoclonal Antibody detects endogenous levels of Shc protein.
Purification Affinity purification
Concentration 1mg/ml
Format Liquid
Formulation In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol.
Shipping Gel Pack
Storage Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks.
Research Use For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Application Key

WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IHC-P-Immunohistochemistry-Paraffin
IF
-Immunofluorescence ICC-Immunocytochemistry FC-Flow Cytometry

Reactivity Key

H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish
Hr
-Horse All-All Species Expected

Product Bioinformatics
Synonym(s) SHC adaptor protein 1; SHC; SHCA; SHC1
Gene Aliases SHC1
UniProt ID

P29353

Entrez Gene ID

6464

Product Description

Shc also known as SHCA, SHC1 is a critical adapter protein that plays a pivotal role in signaling pathways activated by receptor tyrosine kinases, which are essential for various cellular responses, including growth and differentiation. Located primarily in the cytoplasm, Shc acts as a molecular bridge, linking activated receptors to downstream signaling molecules, thereby facilitating signal transmission to the nucleus. This function allows cells to respond appropriately to external growth signals, ensuring proper cellular function and homeostasis. Notably, Shc interacts with other key proteins, such as GRB2 and Sos, to activate the Ras signaling pathway, which is vital for cell proliferation and survival. 

Product Image Gallery
Specific Protocols
>> Western Blotting Protocol >> Immunoprecipitation Protocol
>> Immunohistochemistry Protocol >> Immunofluorescence Protocol
>> Immunocytochemistry Protocol >> Flow Cytometry Protocol
>> ChIP Protocol >> ELISA Protocol
>> HPLC Protocol >> PCR Protocol
For Research Use Only, Not For Diagnostic Or Therapeutic Procedures.
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