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Pyk2 Rabbit Monoclonal Antibody
Catalog #:EAB22822
  SKU-Pack Size Availability Size Price
EAB22822-100UL In Stock 100ul ¥2290.00
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2 / F, 128 malianwa North Road, Haidian District, E-mail:   mrkbio@163.com 
China Beijing China Website: www.mrkbio.com
Product Information
Applications WB, IP, IHC-P, IF/ICC
Species Reactivity Human, Mouse, Rat
Host / Isotype Rabbit IgG
Clonality Monoclonal
Applications Dilutions WB=1:1000-5000 
IP=1:10-100
IHC-P=1:100-500 
IF/ICC=1:100-500
MW (kDa) 116
Conjugate Unconjugate
Specificity Pyk2 Rabbit Monoclonal Antibody detects endogenous levels of Pyk2 protein.
Purification Affinity purification
Concentration 1mg/ml
Format Liquid
Formulation In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol.
Shipping Gel Pack
Storage Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks.
Research Use For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Application Key

WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IHC-P-Immunohistochemistry-Paraffin
IF
-Immunofluorescence ICC-Immunocytochemistry FC-Flow Cytometry

Reactivity Key

H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish
Hr
-Horse All-All Species Expected

Product Bioinformatics
Synonym(s) Protein tyrosine kinase 2 beta; PKB; PTK; CAKB; FAK2; PYK2; CADTK; FADK2; RAFTK; PTK2B
Gene Aliases PTK2B
UniProt ID

Q14289

Entrez Gene ID

2185

Product Description

Pyk2 is a cytoplasmic protein tyrosine kinase which is involved in calcium-induced regulation of ion channels and activation of the map kinase signaling pathway. Pyk2 plays a crucial role in cellular signaling, particularly in the central nervous system, where Pyk2 is highly expressed. Pyk2 is involved in the modulation of ion channel function and the activation of the mitogen-activated protein kinase (MAPK) signaling pathway, which are essential for various cellular processes, including growth, differentiation, and response to stress. The activation of Pyk2 occurs rapidly in response to stimuli that elevate intracellular calcium levels, as well as through the action of phorbol esters that activate protein kinase C (PKC) family members. Notably, Pyk2 undergoes significant post-translational modifications, including phosphorylation on tyrosine residues, which are critical for function and regulation. These modifications not only enhance kinase activity but also facilitate interactions with other signaling proteins, thereby amplifying the cellular response to external signals. 

Product Image Gallery
Specific Protocols
>> Western Blotting Protocol >> Immunoprecipitation Protocol
>> Immunohistochemistry Protocol >> Immunofluorescence Protocol
>> Immunocytochemistry Protocol >> Flow Cytometry Protocol
>> ChIP Protocol >> ELISA Protocol
>> HPLC Protocol >> PCR Protocol
For Research Use Only, Not For Diagnostic Or Therapeutic Procedures.
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