O60934

p95/NBS1 also known as NBS, NBS1, P95, NBN, Nibrin is a component of the MRE11/RAD50/NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity, particularly in repairing double-strand breaks, which are among the most lethal forms of DNA damage. p95/NBS1 functions as part of a complex with Mre11 and Rad50, forming the MRE11/RAD50/NBS1 (MRN) complex that is essential for recognizing and processing DNA breaks. p95/NBS1′s importance is underscored by its absence in Nijmegen breakage syndrome (NBS) patients, who exhibit increased sensitivity to ionizing radiation and predisposition to cancer due to defective DNA repair mechanisms.