Monoclonal Antibodies - PMS2 Mouse Monoclonal Antibody

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PMS2 Mouse Monoclonal Antibody

Catalog #：EAB21241

Datasheet

SKU-Pack Size	Availability	Size	Price
EAB21241-30UL	In Stock	30ul	$133.50
EAB21241-100UL	In Stock	100ul	$298.50

If you want to get a larger packsize, Please contact your local distributor or
email us at info@ebiocell.com

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	EbioCell	Phone：(540) 808-3925
	Imperial Business Park 4819 Emperor Boulevard,	E-mail：order@ebiocell.com
United States	Suite 408 Durham, NC 27703, USA	Web：www.ebiocell.com

Product Information
Applications	WB, IF/ICC, FC, ELISA
Species Reactivity	Human
Host / Isotype	Mouse IgG2b
Clonality	Monoclonal
Applications Dilutions	WB=1:500-2000　　 IF/ICC=1:100-500　 FC=1:50-200
MW (kDa)	96
Conjugate	Unconjugate
Specificity	PMS2 Mouse Monoclonal Antibody detects endogenous levels of PMS2 protein.
Purification	Affinity purification
Concentration	1mg/ml
Format	Liquid
Formulation	In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol.
Shipping	Gel Pack
Storage	Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks.
Research Use	For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Application Key WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IHC-P-Immunohistochemistry-Paraffin IF-Immunofluorescence ICC-Immunocytochemistry FC-Flow Cytometry
Reactivity Key H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish Hr-Horse All-All Species Expected

Product Bioinformatics
Synonym(s)	MLH4; PMS-2; PMSL2; HNPCC4; LYNCH4; MMRCS4; PMS2CL; PMS2
Gene Aliases	PMS2
UniProt ID	P54278
Entrez Gene ID	5395

Product Description

PMS2 also known as MLH4, PMS2CL is a key component of the mismatch repair system. PMS2 plays a critical role in the DNA mismatch repair (MMR) system, which maintains genomic stability by correcting errors during DNA replication. Deficiencies in this repair mechanism can lead to an accumulation of mutations, increasing the risk of various cancers, including hereditary nonpolyposis colorectal cancer (HNPCC). The identification of PMS2 mutations in HNPCC patients highlights PMS2′s importance in cancer predisposition and potential as a biomarker for tumorigenesis. PMS2 interacts with other key proteins in the MMR pathway, such as MLH1, forming a functional complex crucial for the repair process.

Product Image Gallery
Western blot analysis of extracts on Hela cells, using PMS2 Mouse Monoclonal Antibody (EAB21241) at 1:1000 dilution. Secondary antibody Goat Anti-Mouse IgG (H&L)-HRP (EAB21001) at 1:5000 dilution.

Specific Protocols

>>	Western Blotting Protocol	>>	Immunoprecipitation Protocol
>>	Immunohistochemistry Protocol	>>	Immunofluorescence Protocol
>>	Immunocytochemistry Protocol	>>	Flow Cytometry Protocol
>>	ChIP Protocol	>>	ELISA Protocol
>>	HPLC Protocol	>>	PCR Protocol