Monoclonal Antibodies - SREBP-1 Mouse Monoclonal antibody

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SREBP-1 Mouse Monoclonal antibody

Catalog #：EAB22797

Datasheet

	SKU-Pack Size	Availability	Size	Price
	EAB22797-100UL	In Stock	100ul	￡284.90

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email us at info@ebiocell.com

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	CUlabSciences	Phone：+44 (0) 1232 330008
	Cambridge House St Thomas' Place Ely,	E-mail：sales@culabsciences.co.uk
United Kingdom	Cambridge CB27 9RD UK	Web：www.culabsciences.co.uk

Product Information
Applications	WB, IP, IHC-P, IF/ICC, ELISA
Species Reactivity	Human, Bovine
Host / Isotype	Mouse IgG1
Clonality	Monoclonal
Applications Dilutions	WB=1:1000-5000　 IP=1:50-200 IHC-P=1:100-500　 IF/ICC=1:100-500
MW (kDa)	122
Conjugate	Unconjugate
Specificity	SREBP-1 Mouse Monoclonal antibody detects endogenous levels of SREBP-1 protein.
Purification	Affinity purification
Concentration	1mg/ml
Format	Liquid
Formulation	In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol.
Shipping	Gel Pack
Storage	Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks.
Research Use	For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Application Key WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IHC-P-Immunohistochemistry-Paraffin IF-Immunofluorescence ICC-Immunocytochemistry FC-Flow Cytometry
Reactivity Key H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish Hr-Horse All-All Species Expected

Product Bioinformatics
Synonym(s)	Sterol regulatory element binding transcription factor 1; HMD; IFAP2; SREBP1; bHLHd1; SREBF1
Gene Aliases	SREBF1
UniProt ID	P36956
Entrez Gene ID	6720

Product Description

SREBP-1 also known as SREBF1 is a basic helix-loop-helix-leucine zipper (bHLH-Zip) transcription factor that binds to the sterol regulatory element-1 (SRE1). SREBP-1 plays a crucial role in lipid metabolism by regulating the expression of genes involved in cholesterol and fatty acid synthesis. SREBP-1 is primarily located in the endoplasmic reticulum and the nuclear envelope, where SREBP-1 exists as a precursor form. Upon sterol depletion, SREBP-1 undergoes proteolytic cleavage, releasing a soluble fragment that translocates to the nucleus to activate transcription of target genes, thereby enhancing the uptake of low-density lipoprotein (LDL) and promoting lipid biosynthesis. The regulation of SREBP-1 is vital for maintaining cellular lipid homeostasis, as excessive cholesterol accumulation can lead to various metabolic disorders.

Product Image Gallery
Western blot analysis of extracts on Hela, A549, MCF7 cells, using SREBP-1 Mouse Monoclonal antibody (EAB22797) at 1:3000 dilution. Secondary antibody Goat Anti-Mouse IgG (H&L)-HRP (EAB21001) at 1:5000 dilution.

Specific Protocols

>>	Western Blotting Protocol	>>	Immunoprecipitation Protocol
>>	Immunohistochemistry Protocol	>>	Immunofluorescence Protocol
>>	Immunocytochemistry Protocol	>>	Flow Cytometry Protocol
>>	ChIP Protocol	>>	ELISA Protocol
>>	HPLC Protocol	>>	PCR Protocol