Monoclonal Antibodies - GTBP/MSH6 Mouse Monoclonal Antibody

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GTBP/MSH6 Mouse Monoclonal Antibody

Catalog #：EAB21243

Datasheet

SKU-Pack Size	Availability	Size	Price
EAB21243-30UL	In Stock	30ul	€115.70
EAB21243-100UL	In Stock	100ul	€258.70

If you want to get a larger packsize, Please contact your local distributor or
email us at info@ebiocell.com

Please select the country you are in to find your local distributor.

	Dianost	Phone：+49 (0) 40 65472-053
	Bullenkoppel 11， 23896 Poggensee,	E-mail：ola@olasciences.com
Germany	Germany	Web：www.olasciences.com

Product Information
Applications	WB, IHC-P, IF/ICC, FC, ELISA
Species Reactivity	Human
Host / Isotype	Mouse IgG2a
Clonality	Monoclonal
Applications Dilutions	WB=1:500-2000　 IHC-P=1:100-500　 IF/ICC=1:100-500　 FC=1:50-200
MW (kDa)	153
Conjugate	Unconjugate
Specificity	GTBP/MSH6 Mouse Monoclonal Antibody detects endogenous levels of GTBP/MSH6 protein.
Purification	Affinity purification
Concentration	1mg/ml
Format	Liquid
Formulation	In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol.
Shipping	Gel Pack
Storage	Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks.
Research Use	For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Application Key WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IHC-P-Immunohistochemistry-Paraffin IF-Immunofluorescence ICC-Immunocytochemistry FC-Flow Cytometry
Reactivity Key H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish Hr-Horse All-All Species Expected

Product Bioinformatics
Synonym(s)	MutS homolog 6; GTBP; HSAP; p160; GTMBP; MSH-6; HNPCC5; LYNCH5; MMRCS3; MSH6
Gene Aliases	MSH6
UniProt ID	P52701
Entrez Gene ID	2956

Product Description

MSH6 also known as GTBP is a member of the DNA mismatch repair MutS family. MSH6 plays a crucial role in DNA mismatch repair pathway, which maintains genomic stability by correcting DNA replication errors. MSH6 is primarily located in the nucleus, where MSH6 forms a heterodimer with MSH2 to recognize and bind to G/T mismatches in DNA. This interaction initiates a cascade of events leading to excision and resynthesis of erroneous DNA segments. MSH6′s importance in this pathway is underscored by MSH6′s association with hereditary nonpolyposis colorectal cancer (HNPCC), where mutations in mismatch repair genes lead to microsatellite instability and increased cancer risk.

Product Image Gallery

Western blot analysis of extracts on A549, HepG2, MCF7, HEK293 cells, using GTBP/MSH6 Mouse Monoclonal Antibody (EAB21243) at 1:1000 dilution. Secondary antibody Goat Anti-Mouse IgG (H&L)-HRP (EAB21001) at 1:5000 dilution.

Predicted band size: 153 kDa; Observed band size: 160 kDa

Immunohistochemical analysis of paraffin-embedded Human colon cancer tissue, using GTBP/MSH6 Mouse Monoclonal Antibody (EAB21243) at 1:200 dilution.

Specific Protocols

>>	Western Blotting Protocol	>>	Immunoprecipitation Protocol
>>	Immunohistochemistry Protocol	>>	Immunofluorescence Protocol
>>	Immunocytochemistry Protocol	>>	Flow Cytometry Protocol
>>	ChIP Protocol	>>	ELISA Protocol
>>	HPLC Protocol	>>	PCR Protocol