P05107

Integrin β2 also known as ITGB2, CD18 is an integrin beta chain, which combines with multiple different alpha chains to form different integrin heterodimers. Integrin β2 plays a crucial role in cell adhesion and signaling, functioning as a key component of integrin heterodimers that mediate interactions between cells and the extracellular matrix. Integrin β2 is primarily located on the cell surface, where Integrin β2 forms heterodimers with integrin α subunits, facilitating the binding of ligands such as fibronectin, collagen, and vitronectin. This binding is essential for various biological processes, including cell migration, immune response, and tissue repair. Proper localization of Integrin β2 at the cell membrane is vital for function, as such positioning allows for dynamic regulation of cell adhesion and signaling pathways that influence cellular behavior.