Recombinant Antibodies - Neurofilament-L/NF-L Rabbit Monoclonal Antibody

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Neurofilament-L/NF-L Rabbit Monoclonal Antibody

Catalog #：EAB22444

Datasheet

	SKU-Pack Size	Availability	Size	Price
	EAB22444-100UL	In Stock	100ul	€297.70

If you want to get a larger packsize, Please contact your local distributor or
email us at info@ebiocell.com

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	Cambiotech	Phone：+44 (0) 188 448801
	Lanwades Business Park,	E-mail：info@cambiotech.com
Ireland	Kobenhavn K, Ireland	Web：www.cambiotech.com

Product Information
Applications	WB, IP, IHC-P, IF/ICC
Species Reactivity	Human, Mouse, Rat
Host / Isotype	Rabbit IgG
Clonality	Monoclonal
Applications Dilutions	WB=1:1000-5000　 IP=1:10-100 IHC-P=1:100-500　 IF/ICC=1:100-500
MW (kDa)	62
Conjugate	Unconjugate
Specificity	Neurofilament-L/NF-L Rabbit Monoclonal Antibody detects endogenous levels of Neurofilament-L/NF-L protein.
Purification	Affinity purification
Concentration	1mg/ml
Format	Liquid
Formulation	In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol.
Shipping	Gel Pack
Storage	Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks.
Research Use	For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Application Key WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IHC-P-Immunohistochemistry-Paraffin IF-Immunofluorescence ICC-Immunocytochemistry FC-Flow Cytometry
Reactivity Key H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish Hr-Horse All-All Species Expected

Product Bioinformatics
Synonym(s)	Neurofilament light chain; NFL; NF-L; NF68; CMT1F; CMT2E; CMTDIG; PPP1R110; NEFL
Gene Aliases	NEFL
UniProt ID	P07196
Entrez Gene ID	4747

Product Description

NF-L(Neurofilament-L) also known as NEFL is a crucial component of the neuronal cytoskeleton. NF-L plays a significant role in maintaining the structural integrity of neurons. Located primarily in the axons of neurons, NF-L contributes to the regulation of axon caliber, which is essential for proper nerve signal conduction. The dynamic nature of neurofilaments allows them to interact with other cytoskeletal elements, such as microtubules and actin filaments, thereby influencing overall neuronal function and stability. Importantly, alterations in NF-L phosphorylation and metabolism are often associated with neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS), Parkinson′s disease, and Alzheimer′s disease, making NF-L a valuable biomarker for studying these conditions.

Product Image Gallery
Western blot analysis of extracts on Mouse brain, Rat brain cells, using Neurofilament-L/NF-L Rabbit Monoclonal Antibody (EAB22444) at 1:1000 dilution. Secondary antibody Goat Anti-Rabbit IgG (H&L)-HRP (EAB21002) at 1:5000 dilution.

Specific Protocols

>>	Western Blotting Protocol	>>	Immunoprecipitation Protocol
>>	Immunohistochemistry Protocol	>>	Immunofluorescence Protocol
>>	Immunocytochemistry Protocol	>>	Flow Cytometry Protocol
>>	ChIP Protocol	>>	ELISA Protocol
>>	HPLC Protocol	>>	PCR Protocol