Polyclonal Antibodies - APC8/Cdc23 Rabbit Polyclonal Antibody

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APC8/Cdc23 Rabbit Polyclonal Antibody

Catalog #：EAB12119

Datasheet

SKU-Pack Size	Availability	Size	Price
EAB12119-30UL	In Stock	30ul	€115.70
EAB12119-100UL	In Stock	100ul	€258.70
EAB12119-200UL	In Stock	200ul	€440.70

If you want to get a larger packsize, Please contact your local distributor or
email us at info@ebiocell.com

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	Dianost	Phone：+49 (0) 40 65472-053
	Bullenkoppel 11， 23896 Poggensee,	E-mail：ola@olasciences.com
Germany	Germany	Web：www.olasciences.com

Product Information
Applications	WB, ELISA
Species Reactivity	Human, Mouse, Monkey
Host / Isotype	Rabbit IgG
Clonality	Polyclonal
Applications Dilutions	WB=1:500-2000
MW (kDa)	69
Conjugate	Unconjugate
Specificity	APC8/Cdc23 Rabbit Polyclonal Antibody detects endogenous levels of APC8/Cdc23 protein.
Purification	Affinity purification
Concentration	1mg/ml
Format	Liquid
Formulation	In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol.
Shipping	Gel Pack
Storage	Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks.
Research Use	For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Application Key WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IHC-P-Immunohistochemistry-Paraffin IF-Immunofluorescence ICC-Immunocytochemistry FC-Flow Cytometry
Reactivity Key H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish Hr-Horse All-All Species Expected

Product Bioinformatics
Synonym(s)	Cell division cycle 23; APC8; CUT23; ANAPC8; CDC23
Gene Aliases	CDC23
UniProt ID	Q9UJX2
Entrez Gene ID	8697

Product Description

APC8 also known as Cdc23 is a component of the tetratricopeptide repeat (TPR) APC/C sub-complex that also includes APC3 (CDC27) and APC6 (CDC16). APC8 plays a crucial role in the anaphase-promoting complex (APC), which is essential for proper cell cycle progression. APC8 functions as a component of APC that facilitates ubiquitination of mitotic cyclins and other regulatory proteins, promoting sister chromatid separation during metaphase to anaphase transition in mitosis. This process ensures accurate chromosome segregation, which maintains genomic stability and prevents aneuploidy, a condition often associated with cancer. APC8 contains nine tetratricopeptide repeat (TPR) units, which mediate protein-protein interactions, enabling APC to function effectively.

Product Image Gallery
Western blot analysis of extracts on NIH/3T3, 293 cells, using APC8/Cdc23 Rabbit Polyclonal Antibody (EAB12119) at 1:1000 dilution. Secondary antibody Goat Anti-Rabbit IgG (H&L)-HRP (EAB21002) at 1:5000 dilution.

Specific Protocols

>>	Western Blotting Protocol	>>	Immunoprecipitation Protocol
>>	Immunohistochemistry Protocol	>>	Immunofluorescence Protocol
>>	Immunocytochemistry Protocol	>>	Flow Cytometry Protocol
>>	ChIP Protocol	>>	ELISA Protocol
>>	HPLC Protocol	>>	PCR Protocol