ILK1 also known as P59, ILK is a protein with a kinase-like domain and four ankyrin-like repeats. ILK1 plays a crucial role in cellular signaling and is primarily located at the cell membrane, where ILK1 interacts with integrins, which are essential for cell adhesion and communication with the extracellular matrix. This localization enables ILK1 to mediate the transduction of signals that influence various biological processes, including cell growth, differentiation, and migration. ILK1 interaction with integrins facilitates the assembly of the cytoskeleton and promotes cellular responses to external stimuli, thereby impacting tissue development and repair. ILK1 has been implicated in tumorigenesis, as expression levels can influence the behavior of cancer cells, making ILK1 a significant target for research in cancer biology.