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Forskolin (CAS: 66575-29-9)
Catalog #:EBC51097
  SKU-Pack Size Availability Size Price
EBC51097-1ML In Stock 1mL(10mM in DMSO) ¥590.00
EBC51097-1MG In Stock 25mg ¥690.00
EBC51097-50MG In Stock 50mg ¥990.00
EBC51097-100MG In Stock 100mg ¥1690.00
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Product Information
Synonym(s) Coleonol, Adenylyl cyclase activator
Chemical Name (3R,4aR,5S,6S,6aS,10S,10aR,10bS)-Dodecahydro-6,10,10b-trihydroxy-3,4a,7,7,10a-pentamethyl-1-oxo-3-vinyl-1H-benzo[f]chromen-5-yl acetate
Application Forskolin is an adenylate cyclase activator and MAP kinase inhibitor
CAS Number 66575-29-9
Purity ≥98.0%
Molecular Weight 410.50
Molecular Formula C₂₂H₃₄O₇
SMILES CC(=O)O[C@H]2[C@@H](O)[C@@H]1[C@](C)([C@@H](O)CCC1(C)C)[C@@]3(O)C(=O)C[C@](C)(C=C)O[C@]23C
Target & IC50 MAP kinase: IC50 = 25 μM
adenylyl cyclase: IC50 = 41 nM
Solubility DMSO: 30 mg/mL (73 mM)
Ethanol: 15 mg/mL (36.5 mM)
Preparing Stock Solutions
ConcentrationSolventMass 1 mg 5 mg 10 mg
1 mM 2.4361 ml 12.1803 ml 24.3605 ml
5 mM 0.4872 ml 2.4361 ml 4.8721 ml
10 mM 0.2436 ml 1.2180 ml 2.4361 ml
50 mM 0.0487 ml 0.2436 ml 0.4872 ml
Shipping Gel Pack
Storage Store at -20°C
Research Use For Research Use Only. Not Intended for Diagnostic Or Therapeutic Use.
Product Description

Forskolin is a diterpenoid isolated from Coleus forskohlii, interacts directly with the catalytic subunit of A cyclase (adenylate cyclase), activating the enzyme and raising intracellular levels of cAMP. Forskolin is cell permeable and active in vivo producing positive inotropic, platelet anti-aggregatory and anti-hypertensive effects in vitro. Has also been shown to exhibit smooth muscle relaxant activity, decrease in intraocular pressure and the promotion of hormonal release from the pituitary glands in vitro. Inhibits MAP kinase, induces phosphorylation of CREB, connexin 43, Bad, ATF-1 and PKB. Forskolin is an inhibitor of AChR. 

Specific Protocols
>> Western Blotting Protocol >> Immunoprecipitation Protocol
>> Immunohistochemistry Protocol >> Immunofluorescence Protocol
>> Immunocytochemistry Protocol >> Flow Cytometry Protocol
>> ChIP Protocol >> ELISA Protocol
>> HPLC Protocol >> PCR Protocol
For Research Use Only, Not For Diagnostic Or Therapeutic Procedures.
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