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Fluorouracil (CAS: 51-21-8)
Catalog #:EBC51162
  SKU-Pack Size Availability Size Price
EBC51162-1ML In Stock 1mL(10mM in DMSO) ¥590.00
EBC51162-200MG In Stock 200mg ¥390.00
EBC51162-1G In Stock 1g ¥490.00
EBC51162-5G In Stock 5g ¥990.00
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Product Information
Synonym(s) 5-FU; 2,4-dioxo-5-fluoropyrimidine; 5-Fluorouracil; Efudex; Adrucil; Carac
Chemical Name 5-fluoro-1H-pyrimidine-2,4-dione
Application Fluorouracil is a DNA synthesis blocker which arrests the cell cycle in G2
CAS Number 51-21-8
Purity ≥98.0%
Molecular Weight 130.08
Molecular Formula C₄H₃FN₂O₂
Target & IC50 HeLa: IC50 = 1 μM
L1210 : IC50 = 0.63 μM
HaCaT : IC50 = 0.4 μM
PC-3: IC50 = 16 nM
Solubility DMSO: 100 mg/mL (768.76 mM)
Water: 20 mg/mL (153.75 mM)
Preparing Stock Solutions
ConcentrationSolventMass 1 mg 5 mg 10 mg
1 mM 7.6876 ml 38.4379 ml 76.8758 ml
5 mM 1.5375 ml 7.6876 ml 15.3752 ml
10 mM 0.7688 ml 3.8438 ml 7.6876 ml
50 mM 0.1538 ml 0.7688 ml 1.5375 ml
Shipping Gel Pack
Storage Store at 2-8°C
Research Use For Research Use Only. Not Intended for Diagnostic Or Therapeutic Use.
Product Description

Fluorouracil is a potent antitumor agent that interferes with DNA synthesis via noncompetitive inhibition of thymidylate synthase (TS). The interruption of this enzyme blocks the synthesis of pyrimidine thymidine, a nucleotide required for DNA replication. Fluorouracil Induces apoptosis in human primary and metastatic colon adenocarcinoma cell lines in vitro. It has also been shown to arrest the cell cycle at the G2 phase. Fluorouracil acts as an antimetabolite to uracil. Research in mice has shown that fluorouracil administration may lead to potential degeneration of the CNS by damage to oligodendrocytes responsible for production of myelin sheaths. 

Specific Protocols
>> Western Blotting Protocol >> Immunoprecipitation Protocol
>> Immunohistochemistry Protocol >> Immunofluorescence Protocol
>> Immunocytochemistry Protocol >> Flow Cytometry Protocol
>> ChIP Protocol >> ELISA Protocol
>> HPLC Protocol >> PCR Protocol
For Research Use Only, Not For Diagnostic Or Therapeutic Procedures.
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