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Irinotecan hydrochloride trihydrate (CAS: 136572-09-3)
Catalog #:EBC51163
  SKU-Pack Size Availability Size Price
EBC51163-1ML In Stock 1mL(10mM in DMSO) ¥690.00
EBC51163-100MG In Stock 100mg ¥690.00
EBC51163-200MG In Stock 200mg ¥1090.00
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Product Information
Synonym(s) Camptosar; Campto; CPT-11
Chemical Name (S)-4,11-diethyl-4-hydroxy-3,14-dioxo-3,4,12,14-tetrahydro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-9-yl [1,4'-bipiperidine]-1'-carboxylate hydrochloride trihydrate
Application Irinotecan hydrochloride trihydrate is an inhibitor of Topo I
CAS Number 136572-09-3
Purity ≥99.0%
Molecular Weight 677.18
Molecular Formula C₃₃H₄₅ClN₄O₉
Solubility DMSO: 50 mg/mL (73.84 mM)
Water: 1.52 mg/mL (2.24 mM; Need ultrasonic and warming)
Preparing Stock Solutions
ConcentrationSolventMass 1 mg 5 mg 10 mg
1 mM 1.4767 ml 7.3836 ml 14.7671 ml
5 mM 0.2953 ml 1.4767 ml 2.9534 ml
10 mM 0.1477 ml 0.7384 ml 1.4767 ml
50 mM 0.0295 ml 0.1477 ml 0.2953 ml
Shipping Gel Pack
Storage Store at -20°C
Research Use For Research Use Only. Not Intended for Diagnostic Or Therapeutic Use.
Product Description

Irinotecan hydrochloride trihydrate, Irinotecan (CPT 11), a compound within the camptothecin family, is an inhibitor of Topo I (topoisomerase I) involved in cellular DNA replication and transcription. As a Topo I inhibitor, Irinotecan inhibits the religation step of the enzyme's normal action, inducing single stranded DNA breaks. These single stranded breaks are then converted to double-stranded breaks within the course of DNA replication which is reported to induce apoptosis or repair mechanisms as a result. Irinotecan is activated by esterases to produce the activated metabolite, SN 38 (sc-203697) and has been reported to be associated with cleavage of poly (ADP-ribose) polymerase (PARP) in colon carcinoma cells. Irinotecan's active metabolite SN 38 is additionally noted to activate p53 in the Huh7 cell line. 

Specific Protocols
>> Western Blotting Protocol >> Immunoprecipitation Protocol
>> Immunohistochemistry Protocol >> Immunofluorescence Protocol
>> Immunocytochemistry Protocol >> Flow Cytometry Protocol
>> ChIP Protocol >> ELISA Protocol
>> HPLC Protocol >> PCR Protocol
For Research Use Only, Not For Diagnostic Or Therapeutic Procedures.
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