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MK-886 sodium salt (CAS: 118427-55-7)
Catalog #:EBC51140
  SKU-Pack Size Availability Size Price
EBC51140-1MG In Stock 1mg ¥590.00
EBC51140-5MG In Stock 5mg ¥990.00
EBC51140-10MG In Stock 10mg ¥1490.00
EBC51140-25MG In Stock 25mg ¥2790.00
EBC51140-50MG In Stock 50mg ¥4490.00
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Product Information
Synonym(s) MK 886,MK886, L663536
Chemical Name 3-[1-(p-Chlorobenzyl)-5-(isopropyl)-3-t-butylthioindol-2-yl]-2,2-dimethylpropanoic acid . Na
Application MK-886 sodium salt is a potent and selective inhibitor of FLAP and Cox-1
CAS Number 118427-55-7
Purity ≥98.0%
Molecular Weight 494.06
Molecular Formula C₂₇H₃₃ClNO₂S•Na
SMILES CC(C)C1=CC2=C(C=C1)N(C(=C2SC(C)(C)C)CC(C)(C)C(=O)[O-])CC3=CC=C(C=C3)Cl.[Na+]
Target & IC50 leukotriene: IC50 = 2.5 nM
leukotriene: IC50 = 1.1 μM
Solubility DMSO: 25 mg/mL (50.6 mM)
Ethanol: 25 mg/mL (50.6 mM)
Preparing Stock Solutions
ConcentrationSolventMass 1 mg 5 mg 10 mg
1 mM 2.0240 ml 10.1202 ml 20.2405 ml
5 mM 0.4048 ml 2.0240 ml 4.0481 ml
10 mM 0.2024 ml 1.0120 ml 2.0241 ml
50 mM 0.0405 ml 0.2024 ml 0.4048 ml
Shipping Room Temperature
Storage Room Temperature
Research Use For Research Use Only. Not Intended for Diagnostic Or Therapeutic Use.
Product Description

MK-886 sodium salt, also designated L-663,536, is a potent and selective inhibitor of 5-lipoxygenase-activating protein (FLAP). FLAP is an arachidonic acid binding protein that is critical in the biosynthesis of leukotrienes. Inhibitors of FLAP prevent translocation of 5-lipoxygenase from the cytosol to the membrane and inhibit 5-lipoxygenase (5-LO) activation. MK-886 binds to FLAP with high affinity and prevents the activation of 5-LO, thus inhibiting leukotriene biosynthesis: 2.5 nM in intact leukocytes; 1.1 µM in whole blood. MK-886 sodium salt is an inhibitor of Cox-1, PGE Synthase and PPARα. 

Specific Protocols
>> Western Blotting Protocol >> Immunoprecipitation Protocol
>> Immunohistochemistry Protocol >> Immunofluorescence Protocol
>> Immunocytochemistry Protocol >> Flow Cytometry Protocol
>> ChIP Protocol >> ELISA Protocol
>> HPLC Protocol >> PCR Protocol
For Research Use Only, Not For Diagnostic Or Therapeutic Procedures.
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