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Pifithrin-μ (CAS: 64984-31-2)
Catalog #:EBC51151
  SKU-Pack Size Availability Size Price
EBC51151-1ML In Stock 1mL(10mM in DMSO) ¥590.00
EBC51151-5MG In Stock 5mg ¥590.00
EBC51151-10MG In Stock 10mg ¥790.00
EBC51151-50MG In Stock 50mg ¥1890.00
EBC51151-50MG In Stock 100mg ¥3390.00
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Product Information
Synonym(s) 2-Phenylacetylenesulfonamide, NSC 303580, Pifithrin-mu
Chemical Name 2-Phenylethynesulfonamide
Application Pifithrin-μ is an inhibitor of p53 activity and HSP 70 activity
CAS Number 64984-31-2
Purity ≥98.0%
Molecular Weight 181.2
Molecular Formula C₈H₇NO₂S
Target & IC50 HSP70
Solubility DMSO: 36 mg/mL (198.66 mM)
Ethanol: 36 mg/mL (198.66 mM)
Preparing Stock Solutions
ConcentrationSolventMass 1 mg 5 mg 10 mg
1 mM 5.5185 ml 27.5923 ml 55.1846 ml
5 mM 1.1037 ml 5.5185 ml 11.0369 ml
10 mM 0.5519 ml 2.7592 ml 5.5185 ml
50 mM 0.1104 ml 0.5518 ml 1.1037 ml
Shipping Gel Pack
Storage Store at -20°C
Research Use For Research Use Only. Not Intended for Diagnostic Or Therapeutic Use.
Product Description

Pifithrin-μ is a cell-permeable sulfonamide inhibitor of p53 binding and an anti-apoptotic. Direct inhibition of p53 binding to mitochondria as well as to Bcl-xL and Bcl-2 proteins by Pifithrin-μ has been observed. Pifithrin-μ selectively inhibits p53 translocation to mitochondria without affecting the transactivation function of p53. Pifithrin-μ has been shown to reduce γ-radiation induced cell death in vitro. Unlike pifithrin-α (sc-45050), pifithrin-μ targets only the mitochondrial branch of the p53 pathway without affecting the important transcriptional functions of p53. Pifithrin-μ selectively inhibits HSP 70 (heat shock protein 70) activity.


Specific Protocols
>> Western Blotting Protocol >> Immunoprecipitation Protocol
>> Immunohistochemistry Protocol >> Immunofluorescence Protocol
>> Immunocytochemistry Protocol >> Flow Cytometry Protocol
>> ChIP Protocol >> ELISA Protocol
>> HPLC Protocol >> PCR Protocol
For Research Use Only, Not For Diagnostic Or Therapeutic Procedures.
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