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Y-27632 dihydrochloride (CAS: 129830-38-2)
Catalog #:EBC51165
  SKU-Pack Size Availability Size Price
EBC51165-1ML In Stock 1mL(10mM in DMSO) ¥990.00
EBC51165-10MG In Stock 10mg ¥990.00
EBC51165-50MG In Stock 50mg ¥1990.00
EBC51165-250MG In Stock 250mg ¥7590.00
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Product Information
Synonym(s) Y-27632 (hydrochloride); Y-27632; Y27632 HCl
Chemical Name 4-[(1R)-1-aminoethyl]-N-pyridin-4-ylcyclohexane-1-carboxamide
Application Y-27632 dihydrochloride is a cell permeable inhibitor of ROCK-1 and ROCK-2 which plays an important role in Rho-mediated cell adhesion and smooth muscle contraction.
CAS Number 129830-38-2
Purity ≥99.0%
Molecular Weight 320.26
Molecular Formula C₁₄H₂₃Cl₂N₃O
Target & IC50 ROCK-I: Ki = 140 nM
Solubility DMSO: 300.0 mg/mL (936.7 mM)
Water: 100.0 mg/mL (312.2 mM)
Preparing Stock Solutions
ConcentrationSolventMass 1 mg 5 mg 10 mg
1 mM 3.1225 ml 15.6123 ml 31.2246 ml
5 mM 0.6245 ml 3.1225 ml 6.2449 ml
10 mM 0.3123 ml 1.5612 ml 3.1225 ml
50 mM 0.0625 ml 0.3122 ml 0.6245 ml
Shipping Gel Pack
Storage Store at -2-8°C
Research Use For Research Use Only. Not Intended for Diagnostic Or Therapeutic Use.
Product Description

Y-27632 dihydrochloride is a selective Rho-kinase inhibitor. Y-27632 dihydrochloride suppresses cholinergic nerve-mediated contractions. In addition, studies show that Y-27632 dihydrochloride increases the release of neurotransmitters from cholinergic nerves. Studies conducted on smooth muscle preparations suggest that Y-27632 dihydrochloride suppresses nerve-mediated contractile responses stimulated by acetylcholine and noradrenaline. Furthermore, studies on lung tissue damage in rats suggest that Y-27632 dihydrochloride can restore the damage caused by oleic acid by inhibition of ROCK-1 and ROCK-2. Y-27632 dihydrochloride also inhibits protein kinase C related kinase, PRK2. 

Specific Protocols
>> Western Blotting Protocol >> Immunoprecipitation Protocol
>> Immunohistochemistry Protocol >> Immunofluorescence Protocol
>> Immunocytochemistry Protocol >> Flow Cytometry Protocol
>> ChIP Protocol >> ELISA Protocol
>> HPLC Protocol >> PCR Protocol
For Research Use Only, Not For Diagnostic Or Therapeutic Procedures.
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